Placental transfer of cefotiam dihydrochloride.

Placental Transfer of Respiratory Syncytial Virus-Specific IgG in Iranian Mothers

Background: Respiratory Syncytical virus infection is the most common cause of bronchiolitis and viral pneumonia in infancy. Objective: To investigate the placental transfer of RSV-specific IgG in Iranian mothers. Methods: The antibodies were measured in sera of 146 mother/newborn pairs using a commercially available indirect Enzyme Linked Immunosorbent Assay (ELISA). The studied subjects were ...

Studies on imidocarb dihydrochloride in experimental Babesia ovis infection in splenectomized lambs

High-performance liquid chromatographic assay for cefotiam and d3-cefotiam in human serum.

Cefotiam is a second-generation cephalosporin for parenteral use, and the active moiety of a recently developed ester of cefotiam for oral administration, cefotiam hexetil. In vitro, cefotiam hexetil is partially hydrolysed to the inactive d3-isomer of cefotiam (Fig. 1) [ 11, and to a minor extent d3-cefotiam has also been detected in serum [ 2,3]. This paper describes a high-performance liquid...

Placental Malaria: Decreased Transfer of Maternal Antibodies Directed to Plasmodium falciparum and Impact on the Incidence of Febrile Infections in Infants

The efficacy of mother-to-child placental transfer of antibodies specific to malaria blood stage antigens was investigated in the context of placental malaria infection, taking into account IgG specificity and maternal hypergammaglobulinemia. The impact of the resulting maternal antibody transfer on infections in infants up to the age of 6 months was also explored. This study showed that i) pla...

Prediction of placental drug transfer using the human placental perfusion model.

The placental perfusion model and a newly developed complementary computational model are reviewed. Examples are provided, where the computational model can be applied to adjust drug pharmacokinetic data obtained from the perfusion model to more closely resemble the in vivo placental transfer of therapeutic agents. After modelling the data, placental perfusion experiments can be used to predict...